The Relationship Between Fetuin-A and Bone Mineral Density in Postmenopausal Osteoporosis
Aylin SARI, 1 Turan USLU2
1Department of Physical Medicine and Rehabilitation, Erenköy Physical Medicine and Rehabilitation Hospital, İstanbul, Turkey
2Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Turkey
Keywords: Bone mineral density; fetuin-A; postmenopausal osteoporosis
Objectives: This study aims to evaluate the relationship between fetuin-A and bone mineral density (BMD) in postmenopausal women.
Patients and methods: Between November 2009 and March 2010, 90 participants were enrolled in the study and divided into three groups including 30 patients in each group. Group 1 consisted of patients who were newly diagnosed with postmenopausal osteoporosis, group 2 consisted of patients who were previously diagnosed with postmenopausal osteoporosis and received treatment, and the control group consisted of healthy volunteers with normal postmenopausal BMD values. Serum fetuin-A level was measured using an enzyme-linked immunosorbent assay (ELISA). Anteriorposterior (AP) lumbar spine, femur neck and total femur BMD were evaluated using dual energy X-ray absorptiometry.
Results: A statistically significant relationship was observed between serum fetuin-A levels and BMD scores. As AP lumbar spine, femur neck and total femur BMD values the fetuin-A levels became lower, serum fetuin-A level decreased. Serum fetuin-A level was lower in patients with postmenopausal osteoporosis, compared to the control group. Serum fetuin-A was not affected by osteoporosis treatment in these patients.
Conclusion: Our study results confirm that BMD parameters are associated with fetuin-A and therefore postmenopausal osteoporosis and fetuin-A. Fetuin-A, a marker for bone mineralization, can be used as a biomarker in the diagnosis and treatment of postmenopausal osteoporosis.