M. Kürşat FİDANCI1, Ayhan KILIÇ1, Mustafa GÜLGÜN1, Gökalp BAŞBOZKURT2, Cengizhan AÇIKEL3, Doğan ŞİMŞEK4, Faysal GÖK4, Erkan DEMİRKAYA4,5

1Department of Pediatric Cardiology, Gülhane Military Medical Faculty, Ankara, Turkey
2Department of Pediatrics, Gülhane Military Medical Faculty, Ankara, Turkey
3Department of Biostatistics, Gülhane Military Medical Faculty, Ankara, Turkey
4Department of Pediatric Rheumatology, Gülhane Military Medical Faculty, Ankara, Turkey
5FMF Arthritis Vasculitis and Orphan Disease Research in Pediatric Rheumatology (FAVOR), Ankara, Turkey

Keywords: Cardiac repolarization, Familial Mediterranean fever, JT dispersion, QT dispersion


Objectives: This study aims to determine QT dispersion and JT dispersion, and their relationship with conventional echocardiography values in a group of children with familial Mediterranean fever (FMF).
Patients and methods: The study included 48 FMF patients (26 males, 22 females, mean age 11.10±3.42 years; range 5 to 18 years) as the FMF patients and 31 healthy children (17 males, 14 females, mean age 9.61±2.83 years; range 5 to 17 years) as the healthy controls. Electrocardiography and conventional echocardiography were performed on the FMF patients and healthy controls. Both groups were evaluated with a standard 12-lead electrocardiography. QT, JT and RR distances were measured in both groups. The corrected QT (QTc) and corrected JT (JTc) were calculated. QTcd and corrected JT dispersion (JTcd) were detected.
Results: There was no statistically significant difference between the FMF patients and healthy controls in terms of RR, QT, QTd, QTcd, JT, JTc, JTd, and JTcd measurements and echocardiography parameters. QTc value was higher in the FMF patients than the healthy controls.
Conclusion: QTc value indicates increased ventricular sensitivity and is an important marker of cardiovascular mortality. It has an important effect on sudden cardiac death and arrhythmia. Our study results suggest that electrocardiographic monitoring may be useful in patients with FMF.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.