Siming GAO, Honglin ZHU, Xiaoxia ZUO, Hui LUO

Department of Rheumatology, Xiangya Hospital, Hunan, China

Keywords: Autoimmune disease; cathepsin G; immune reaction; inflammation


Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases. In this article, we discuss the roles of cathepsin G in inflammation, immune reaction, and autoimmune diseases. To our knowledge, this is the first study providing important information about cathepsin G in the pathogenesis of autoimmune diseases and suggesting that cathepsin G may be a new biomarker or treatment target.