Histological Findings of Organizing Pneumonia, Based on Transbronchial Lung Biopsy, May Predict Poor Outcome in Polymyositis and Dermatomyositis: Report of Two Autopsied Cases
Hiroshi OIWA1, Takeshi KONDO2, Masamoto FUNAKI3, Toshiaki MORITO4, Hiroshi YASUI5, Toru KAMIYA6
1Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan
2Department of Rheumatology, Medical Corporation Jr Hiroshima Hospital, Hiroshima, Japan
3Department of General Medicine/Center For Medical Education, Nagoya University Hospital, Nagoya, Japan
4Department of Pathology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan
5Department of Pathology, Rakuwakai Otowa Hospital, Kyoto, Japan
6Department of General Internal Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan
Keywords: Clinically amyopathic dermatomyositis; dermatomyositis; diffuse alveolar damage; organizing pneumonia; polymyositis
Interstitial lung disease in polymyositis and dermatomyositis is a serious complication, associated with poor prognosis. In this article, we describe two cases with histological findings of organizing pneumonia, based on transbronchial lung biopsy. One is a 66-year-old female patient with clinically amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody, and another is a 61-year-old female patient with polymyositis with anti-Jo-1 antibody. Both of our cases rapidly deteriorated to death, and autopsy findings showed diffuse alveolar damage. Our experience indicates that transbronchial biopsy findings of organizing pneumonia may be a poor prognostic factor in clinically amyopathic dermatomyositis and polymyositis, in spite of the profile of myositis-specific antibodies.
Citation: Oiwa H, Kondo T, Funaki M, Morito T, Yasui H, Kamiya T. Histological Findings of Organizing Pneumonia, Based on Transbronchial Lung Biopsy, May Predict Poor Outcome in Polymyositis and Dermatomyositis: Report of Two Autopsied Cases. Arch Rheumatol 2018;33(3):376-380
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.