Department of Rheumatology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Keywords: Corticosteroid, cyclophosphamide, longitudinal myelitis, magnetic resonance imaging, neuro-Behçet’s disease


Behçet’s disease is a chronic, relapsing inflammatory disorder of unknown etiology. Neuro-Behçet’s disease (NBD) occurs in approximately 5 to 49% of patients with Behçet’s disease. Spinal cord involvement is very rare in NBD. In this article, we report a 22-year-old male patient of NBD with longitudinal myelitis involving the entire spinal cord. Patient was admitted with one-week of headache, vomiting, and urinary incontinence. Before admission, he felt motor weakness for two years and had noticed recurrent genital and oral ulcers with a frequency of more than three episodes per year for five years. T2-weighted spinal magnetic resonance images showed hyperintensities within the entire spinal cord. He was diagnosed as NBD with longitudinal myelitis. Intravenous methylprednisolone (120 mg/day) was administered for three days, followed by an oral administration of prednisolone (45 mg/day). In conjunction with the steroid therapy, intravenous cyclophosphamide (0.4 g/week) was administered twice. Rapid improvements were detected after receiving treatments for half a month. NBD associated longitudinal myelitis is really rare. This case provided important implications for the diagnosis and treatment of longitudinal myelitis in NBD patients.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received financial support from the project of Natural Science Foundation of China (No. 81401356) for this article.