Lupus Myositis with Normal Creatinine Kinase Levels Following Adalimumab Use in a Rheumatoid Arthritis Patient
Hani ALMOALLIM, 1, 2 Ahlam ALMASARI, 2 Hadeel KHADAWARDI1
1Department of Medicine, Medical College, Umm Alqura University, Makkah, Saudi Arabia
2Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
Keywords: Adalimumab; anti-TNF therapy; drug-induced lupus erythematosus; lupus myositis
We report a rare case of histopathologically confirmed lupus myositis that developed in a 32-year-old female with seropositive rheumatoid arthritis that had been treated with adalimumab for one year. She had demonstrated excellent response to her arthritis initially but then developed profound muscle weakness with a conversion of her antinuclear antibody and anti-double stranded DNA from negative to strongly positive. Her creatinine kinase levels remained normal. She responded well to high-dose steroid therapy and rituximab.