Unmet needs in psoriatic arthritis, a narrative review
Clementina Lopez-Medina1,2,3,4
, Umut Kalyoncu5, Laure Gossec4,6
1Reina Sofia University Hospital, Rheumatology, Cordoba, Spain
2Maimonides Institute For Biomedical Research From Cordoba, IMIBIC, GC-05 Group, Cordoba, Spain
3University of Cordoba, Medical and Surgical Sciences, Cordoba, Spain
4Sorbonne Université, Inserm, Institut Pierre Louis D'epidémiologie Et De Santé Publique, Paris, France
5Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Türkiye
6Pitié-salpêtrière University Hospital, AP-HP, Rheumatology, Paris, France
Keywords: Diagnosis, management, psoratic arthritis, treatment.
Abstract
Psoriatic arthritis is a chronic rheumatic disease that poses challenges in its diagnosis, evaluation, and management. The heterogeneity in the manifestations and the absence of definitive diagnosis biomarkers often complicates the process of accurate diagnosis. Furthermore, the involvement of multiple disease domains poses difficulties in assessing disease activity and defining the concept of remission. Despite therapeutic advancements, a subset of patients remains refractory to treatment, leading to the emergence of the concept of “difficult-to-treat” patients and the necessity for novel therapeutic approaches (e.g., drugs with novel mechanisms of action; combinations of treatments). This review addresses key unmet needs in psoriatic arthritis, in terms of diagnosis, classification, evaluation, comorbidities and treatment.
Citation: Lopez-Medina C, Kalyoncu U, Gossec L. Unmet needs in psoriatic arthritis, a narrative review. Arch Rheumatol 2024;39(2):159-171. doi: 10.46497/ ArchRheumatol.2024.10710
Conceptualization, draft of the manuscript: C.L.M.; Conceptualization, critical revision of the manuscript: U.K.; Conceptualization, supervision, critical revision of the manuscript: L.G. All the authors approved the final version.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
The data that support the findings of this study are available from the corresponding author upon reasonable request.