Published In
Archives of Rheumatology
Volume 33 · Issue 1 · March 2018
Pages: 033-038
History
Published Online: March 31, 2018
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anthoula CHATZIKYRIAKIDOU
Laboratory of Medical Biology - Genetics, Medical School, Aristotle University, Thessaloniki, Greece
Paraskevi V. VOULGARI
Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
Alexandros A. DROSOS
Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
Anthoula CHATZIKYRIAKIDOU, Paraskevi V. VOULGARI, & Alexandros A. DROSOS. (2018). An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility. Archives of Rheumatology, 33(1), 033–038. https://doi.org/10.5606/ArchRheumatol.2018.6389
Abstract
Objectives: This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp insertion of bradykinin receptor 2 gene, (iv) the -58T>C of bradykinin receptor 2 gene, and (v) the -699G>C of bradykinin receptor 1 gene.
Patients and methods: The study included 136 RA patients (27 males; 109 females; mean age 60.8 years; range 39 to 75 years) and 149 ethnic matching controls (30 males, 119 females; mean age 56.2 years; range 35 to 78 years). Polymerase chain reaction coupled with restriction assay was performed for 587C>T, -58T>C, and -699G>C.
Results: Rheumatoid arthritis patients and controls carried the wild type allele of 587C>T; therefore, produced the high molecular weight kininogen. No significant difference was observed in genotype or allele distribution of the studied functional polymorphisms between RA patients and controls.
Conclusion: Kinin-kallikrein system related genes might not be major RA susceptibility loci.
Similar Articles
Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Volume 33 · Issue 1 · March 2018
Pages
033-038
History
Published Online
March 31, 2018
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
1
Anthoula CHATZIKYRIAKIDOU
Laboratory of Medical Biology - Genetics, Medical School, Aristotle University, Thessaloniki, Greece
2
Paraskevi V. VOULGARI
Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
3
Alexandros A. DROSOS
Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece
Cite this Article
Anthoula CHATZIKYRIAKIDOU, Paraskevi V. VOULGARI, & Alexandros A. DROSOS. (2018). An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility. Archives of Rheumatology, 33(1), 033–038. https://doi.org/10.5606/ArchRheumatol.2018.6389
Outlines