Published In
Archives of Rheumatology
Volume 40 · Issue 2
Pages: 182-188
History
Published Online: June 30, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Volkan Ecesoy
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Hasan Arıcı
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Fadime Pınar Ateş
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Usame Ömer Osmanoğlu
Department of Biostatistics, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Hilal Ecesoy
Department of Physical Therapy and Rehabilitation, Division of Rheumatology, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Ecesoy, V., Arıcı, H., Ateş, F. P., Osmanoğlu, U. Ömer, & Ecesoy, H. (2025). Examining Sirtuin-1 Levels and Inflammation Markers in Behcet’s Disease: A Pilot Study. Archives of Rheumatology, 40(2), 182–188. https://doi.org/10.5152/ArchRheumatol.2025.11042
Abstract
Background/Aims: Assess circulatory Sirtuin-1 (SIRT1) levels in Behcet's disease (BD) and relationships with disease activity and inflammatory markers.
Materials and Methods: Forty BD patients and 40 matched controls. Recorded demographics, disease activity (BDCAF), treatments, organ involvement. Measured CRP, IL-6, TNF-α, and SIRT1 in fasting blood.
Results: CRP, IL-6, TNF-α higher in BD vs controls, regardless of activity. SIRT1 similar across groups and treatments. Patients with vascular + ocular involvement had lower SIRT1 than ocular only.
Conclusion: Circulatory SIRT1 levels are similar in BD and controls but may associate with vascular involvement.
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Article Info
Published In
Journal
Archives of Rheumatology
Volume / Issue
Volume 40 · Issue 2
Pages
182-188
History
Published Online
June 30, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
Volkan Ecesoy
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Hasan Arıcı
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Fadime Pınar Ateş
Department of Biochemistry, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Usame Ömer Osmanoğlu
Department of Biostatistics, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Hilal Ecesoy
Department of Physical Therapy and Rehabilitation, Division of Rheumatology, Karamanoğlu Mehmetbey University, Karaman, Türkiye
Cite this Article
Ecesoy, V., Arıcı, H., Ateş, F. P., Osmanoğlu, U. Ömer, & Ecesoy, H. (2025). Examining Sirtuin-1 Levels and Inflammation Markers in Behcet’s Disease: A Pilot Study. Archives of Rheumatology, 40(2), 182–188. https://doi.org/10.5152/ArchRheumatol.2025.11042
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