1Department of Physical Medicine and Rehabilitation, Hitit University, Faculty of Medicine, Çorum, Turkey
2Department of Chest Diseases, Hitit University, Faculty of Medicine, Çorum, Turkey
3Department of Cardiology, Hitit University Faculty of Medicine, Çorum, Turkey
4Department of Medical Services and Techniques, Vocational School of Health Services Osmangazi University, Eskişehir, Turkey
5Department of Physical Medicine and Rehabilitation, Pamukkale University Faculty of Medicine, Denizli, Turkey

Keywords: Ankylosing spondylitis, cardiopulmonary exercise testing, pulmonary function test, quality of life


Objectives: To evaluate the cardiopulmonary functions and exercise performance of patients with Ankylosing Spondylitis (AS) and to investigate the relationship between these parameters and disease activity, spine mobility and quality of life.
Patients and methods: Forty-five patients with AS (Group1) and 30 control subjects (Group 2) were included in the study. Disease activity was assessed with the Bath AS Disease Activity Index (BASDAI) and spinal mobility measures with the Bath AS Metrology Index (BASMI). The AS Quality of Life (ASQoL) Questionnaire and the Maastricht AS Enthesitis Score (MASES) were used. The pulmonary function test (PFT) and Cardiopulmonary Exercise Testing (CPET) were performed.
Results: The mean age was 43.09±12.07 in Group 1 and 42.80±9.96 in Group 2, with no significant difference between them. The peak expiratory flow (PEF) value in PFT was significantly lower in Group 1 (p<0.05). In Group 1, the duration of CPET was significantly shorter, and maximum work load and MET (Metabolic Equivalent) were significantly lower than in Group 2 (p<0.001). VO2max in peak responses, work and heart rate were significantly lower in Group 1. The duration of CPET and maximum work were negatively correlated with age and BASMI (p<0.001). VO2max was negatively correlated with age, MASES and ASQoL (p<0.05).
Conclusion: There was no significant difference in PFT parameters between the groups. On the other hand, CPET parameters were found to be significantly lower in the AS group. While CPET parameters are affected by spinal mobility, declining aerobic capacity affects quality of life.

Citation: Çağlıyan Türk A, Arslan S, Karavelioğlu Y, Kalcık M, Özel S, Musmul A, et al. Pulmonary function, aerobic capacity and related variables in patients with ankylosing spondylitis. Arch Rheumatol 2019;34(x):i-ix.