Acute Lymphoid Leukemia After Anti-TNF-alpha Treatment: A Case Report and Review of the Literature
Füsun GEDİZ ÖZDEMİRKIRAN1, Bahriye Kadriye PAYZIN1, Eyüp ÇOBAN2, Korhan Barış BAYRAM3, Betül KÜÇÜKZEYBEK4
1Department of Hematology, Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Turkey
2Department of Internal Medicine, Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Turkey
3Department of Physical Medicine and Rehabilitation, Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Turkey
4Department of Pathology, Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Turkey
Keywords: Acute lymphoid leukemia, ankylosing spondylitis, anti-tumor necrosis factor-alpha drugs
Abstract
The efficacy and safety of anti-tumor necrosis factor-alpha drugs have been shown in active ankylosing spondylitis cases that are resistant to traditional disease-modifying antirheumatic drugs. However, it is well known that these drugs may cause some complications as reactivation of tuberculosis and various hematologic malignancies. In this article, we report a 40-year-old male patient with ankylosing spondylitis who developed Philadelphia chromosome-positive acute lymphoid leukemia after treatment with tumor necrosis factor-alpha inhibitors.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.